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Львівський національний медичний університет

Department of pharmacognosy and botany

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 ADDRESS
69 Pekarska str.

79010, Lviv, Ukraine

e-mail: 

tel.+38 (032) 276-88-35, 275-76-22, 278-64-56

 

HEAD OF THE DEPARTMENT

Roman Yevdokymovych Darmohray PhD (Pharm.), Assoc. Prof.

STAFF OF THE DEPARTMENT

  • Responsible person for educational activity - N.V. Shapovalova, PhD (Pharm.), Assoc. Prof.;
  • Responsible person for scientific activity -  L.V.Benzel, PhD (Pharm.), Assoc. Prof.
  • Responsible person for the department web-page - R.M. Lysiuk, Assist. Prof. (English medium);  
  • V.O. Antonyuk, PhD, DSci (Pharm), Prof.; N.M. Vorobets, PhD, DSci (Biol.), Prof.; O.M.Cherpak, PhD (Pharm.), Assoc. Prof.; I.L. Benzel, PhD (Pharm.), sr. teacher; O.Y.Tsal, Assist. Prof.; O.V.Rybak, Assist. Prof.; V.V. Mykhailovska, sr. laboratory assistant;  N.M. Farenyuk, sr. laboratory assistant; M.M. Chepil, sr. laboratory assistant; T.M. Gorlovetska, laboratory assistant; L.V. Panchak, aspirant.
Staff of the department of Pharmacognosy and botany at Danylo Halytsky Lviv National Medical University, 2014 (from left to right): 1st row- Prof. N.M. Vorobets, Assoc. Prof. N.V. Shapovalova,  Assoc. Prof. R. Ye. Darmohray, Assist. Prof. O.Y.Tsal, Assoc. Prof. O.M.Cherpak; 2nd row - sr. laboratory assistant V.V. Mykhailovska, Assist. Prof. R.M. Lysiuk, sr. laboratory assistant N.M. Farenyuk, Assoc. Prof. L.V.Benzel, sr. laboratory assistant M.M. Chepil, sr. teacher I.L. Benzel 
 
 HISTORY OF THE DEPARTMENT

Pharmacognosy was included as a separate subject to the curriculum of Lviv University in 1855 and was taught at the department of Medicine and Surgery. In 1897 the department of Pharmacology was founded in Lviv University. Professor T.V. Vilchynsky was invited to teach the course of morphology and systematization of plants for students of Pharmacy unit (1920-1923). He was a lecturer of the course of pharmacognosy and botany at the department of Pharmacology, headed by a professor V. Koskovsky. 

In 1940 from the Medical department of Lviv University was separated the institute and faculty of Pharmacy and the department of Pharmacognosy headed by a professor T. Vilchynsky. 

In the post-war period, the department, supervised by a professor T. Vilchynsky, alongside with the organization of educational process and scientific research, was engaged in the training of scientific and teaching staff. The major subject of scientific research comprised investigation of the morphological and histological characteristics of medicinal plants and medicinal plant materials with the purpose of their identification. 

In 1929-1964, professor T. Vilchynsky gathered a unique collection of medicinal plants with the total area of 5.5 sq. ha and consisted of up to 1,500 species. The collection included rare samples of MPM species of the tropical and subtropical origin and those growing in temperate zones. A lot of colour tables were prepared to visualize the lecture material. 

The unique collection of Podillyan and Carpathian flora comprised 3,500 herbaria sheets. As a member of All-Union Botanical Society, Professor T.V. Vilchynsky consulted workers of Kholodny Botanical Institute of the Ukrainian Academy of Sciences and botanical gardens of Ukraine concerning investigations of various plant species of Podillya, Precarpathian, Carpathian and Transcarpathian flora, and their introduction into botanical gardens. 

After professor T.V. Vilchynsky retired, the department was headed by an Associate Professor I.P. Karpus (1964-1970).

In the years 1970-1995, head of the Department was a professor L.Ya. Ladna-Rogovska, who promoted investigations on the chemical composition of medicinal plant materials by the students during their laboratory and scientific – experimental work. Associate professor I.M. Bornyak was head of the department in 1995-1999. Academic activity of the department was focused on the improvement of teaching and methodical work to meet requirements of the new teaching programs with their main objective of training specialists of the new generation. 

Beginning with 1998, the year when English medium students were first admitted to the University, staff of the department has been worked at the development of methodical instructions, texts of lectures and other materials, issued in English.    

Associate Professor R.Y. Darmogray was appointed the head of Pharmacognosy and botany department on July 1, 1999.

In 2008, in honour of the 120th anniversary of the birth, on the house in a botanical garden, where was established the Department of Pharmacognosy, a plaque for a professor Tadeush Vilchynsky was erected. 

BOTANICAL GARDEN      

Botanical garden was founded by a professor of Botany Tadeush Vilchynsky in 1929-1930 and incorporated to the pharmaceutical department of Medical Faculty in Lviv University. Since 1964 collection areas of medicinal plants and dendriform park were declared the objects of nature preservation.

The botanical garden currently occupies the area of 1.5 sq. ha with the educational premises for studying of botany, collections of medicinal plants, greenhouses of tropical and subtropical plants.

    Botanical garden, as a structural subdivision of the Department, is the base for practical training in pharmacognosy and pharmaceutical botany and is engaged in growing and introduction of about 900 taxons of medicinal and other useful plants, preservation of 35 rare and endangered plants. The most interesting and unique is the collection of medicinal plants, structured due to the content of major biologically active substances.

  Collection funds of the plants are used for teaching of Pharmacy students, scientific research on detection of biologically active substances, conducted by the department staff, and search for new perspective plant species for application in medical practice.

    Major objectives of the Botanical garden activity are preservation, investigation, reproduction of the medicinal plant resources in the conditions of cultivation of the regional and world flora and effective employment of the skills in teaching pharmacognosy and botany.      

    Pharmacy students are educated in nature protection, rational uses of medicinal plant resources and agriculture of medicinal plants. Main directions of scientific activities of the garden co-workers comprise plant introduction and acclimatization, investigation and protection of the unique regional phytogenofund and its rational utilization.

Experience of the Botanical garden activities and abundant species of plants cultivated in the garden facilitate the teaching and learning of reproduction, peculiarities of development and vegetation of medicinal plants of Podillya and Opillya (the western part of Ukraine).

     The Botanical garden of Danylo Halytsky Lviv National Medical University takes an active part in the international collaboration on current problems of preservation, utilization and development of botanical gardens, in the exchange of scientific information and cooperative expeditions

MAJOR TRENDS OF SCIENTIFIC RESEARCH

Pharmacognostic research of insufficiently investigated plants of western region of Ukraine with the purpose to develop new medications and biologically active supplements on their basis is carrying out. 

Resource, morphological and histological, chemical and pharmacological researches of plants, medicinal plant materials and obtaining of biologically active substances are being conducted at the department, including elaboration of analytical and normative documentation projects for monographs for medicinal plant materials, phytosubstances and phytopharmaceuticals. 

Associate professor R.Ye. Darmohray carries out the pharmacognostic investigation of the Asteraceae, Fabaceae, Apiaceae, Polygonaceae as promising sources of bioactive substances, their chemotaxonomic studies. He is an author of above 104 scientific, educational and methodical works.

Assoc. professor L.V. Benzel investigates natural plant sources of phenolic compounds, alkaloids, polysaccharides within the Western part of Ukraine with interferon–inducing, immunomodulating, anti-inflammatory, anaestetic and antimicrobial activities. He is an author of 370 scientific publications, including 6 copyright certificates for the inventions, 44 patents of Ukraine, 9 monographs, 15 educational and methodical manuals (10 are recommended by the Central Methodical Committee of the Ministry of Public Health, the Ministry of Education and Sciences of Ukraine), 2 Temporary Pharmacopoeia Monographs, 13 methodical recommendations, 13 informative letters. 

Assoc. professor N.V. Shapovalova is engaged in pharmacognostic study of medicinal plants, containing phenolic compounds and essential oils, development and creation on their basis of phytopharmaceuticals and aromatherapeutic remedies, biologically active supplements. Her research interests include fundamentals and improving of teaching of Pharmacognosy, resources of medicinal plants, specialization "Medicinal plants and phytotherapy" in terms of credit-modular system of educational process. She is an author of 38 publications, among them 1 monograph, 1 typical curriculum, 4 educational manuals, 13 educational and methodical works. 

Professor V.O. Antonyuk obtains and investigates lectins from plants and higher fungi, their application in cytological and histochemical studies. Author of 154 scientific papers, including 1 monograph, 2 manuals, 8 certificates, 5 patents of Ukraine.

Professor N.M. Vorobets is an author of over 130 scientific works, 20 educational publications. Her research interests concern the pharmacognostic study of plants of the western part of Ukraine, investigation on resistance of medicinal plants to heavy metals, possible application for phytoremediation purposes, and pollen dynamics of allergogenic plants of the Lviv region.

Assoc. professor O.M. Cherpak investigates the diagnostic morphological and anatomic characters of medicinal plants and carries out the phytochemical research of plant which exhibit antimicrobial and anticoagulant activities. She is an author of above 40 scientific publications, which include 1 monograph, 4 patents of Ukraine, 1 manual, 3 methodical recommendations, 1 test questions manual. She is an expert of testing center in preparation of the test tasks on pharmaceutical botany to the State licensing examination „Krok 1”.

Sr. teacher I.L. Benzel carries out the pharmacognostic study of natural plant sources of phenolics, that possess interferoninducing, antiviral, antimicrobial and immunomodulatory properties. Author of 77 scientific publications, including 2 manuals, 1 monograph, 2 letters of the Ministry of Public Health of Ukraine, 10 patents of Ukraine and 1 methodical recommendation.

Assist. professor O.Y. Tsal searches for promising plant species of folk medicine of the western region of Ukraine with the purpose of their pharmacognostic investigation and development of new medicines. She is an author of 38 scientific publications, including 1 patent of Ukraine, 3 educational manuals, 2 methodical recommendations. 

Assist. professor O.V. Rybak works on pharmacognostic investigation of the Lamiaceae, Clusiaceae, Rosaceae and Asteraceae species. She is an author of 50 scientific works, including 1 patent of Ukraine, 1 educational manual, 4 methodical recommendations. 

Assist. professor R.M. Lysiuk investigates the plants of hypoazotemic action, and natural sources of polysaccharides. Research interests also comprise principles and improving of teaching of Pharmacognosy for English-medium students. Author of 35 scientific publications, including 2 manuals (2 are recommended by the Ministry of Education and Sciences, Youth and Sports of Ukraine), 1 electronic textbook, 5 educational and methodical recommendations

ACADEMIC ACTIVITY 

The department provides courses of the following subjects: Pharmaceutical botany, Pharmacognosy, Resources of medicinal plants, elective course Phytotherapy for the students of Pharmacy faculty in specialties “Pharmacy” and “Clinical Pharmacy”, Pharmacognostic principles of phytotherapy for the specialty “Clinical Pharmacy”. The students of full-time and distance forms of education get knowledge and skills in Ukrainian, Russian and English media.  Specialization course "Medicinal plants and phytotherapy" is taught by the staff of the Department for students of the Pharmacy Faculty.  

According to the order # 317 of the Ministry of Public Health of Ukraine, the department of Pharmacognosy and botany is basic in the educational subject “Pharmacognosy” for higher educational establishments of ІІІ-ІV accreditation levels of medical (pharmaceutical) profile, holds annual meetings - seminars on topical issues of the educational process of Pharmacognosy and its methodological basis.

Lectures and lab practices are provided by teaching and methodical materials, such as tables, schemes, microsections, herbaria samples of medicinal plants, medicinal plants materials and phytopharmaceuticals.

The library of scientific and reference literature on medicinal plants and unique museum of plant materials from around the world, which counts more than 1000 samples of plant organs, occur at the department. 

5 items of software, computer database about vegetation of planet were developed at the department. The computer database is formed and it includes lecture materials, tasks of test control and independent work, educational and questionnaire program Quiz. The model of modern educational lab and special own computer network, providing computerization in educational process and independent work of students in academic laboratories, carrying out of final  test control have been worked out. 

6 videofilms concerning cell histological structure, tissues and organs, history of foundation of the department and botanical garden of medicinal plants of Danylo Halytsky Lviv National Medical University, summer training students’ practice in a specialized phytocompany "Rhaiduga'' in the Likarske village (Simferopol district, Crimea) have been created at the department. 

BASIC ACHIEVEMENTS OF THE DEPARTMENT 

For the latest 5 years have been published 3 monographs, 16 educational manuals (6 are recommended by the Central Methodical Committee of the Ministry of Public Health of Ukraine, 1 is recommended by the Ministry of Education and Sciences, Youth and Sports of Ukraine), 17 methodical recommendations (1 are recommended by the Central Methodical Committee of the Ministry of Public Health of Ukraine), 3 informative letters, 1 electronic textbook, 35 journal articles, about 40 other publications; and 25 patents of Ukraine were received. 3 PhD dissertations have been defended.

  • Main publications of academic, methodical and monographic character for the latest years comprise:
  • Дармограй Р.Є., Бензель Л.В., Шаповалова Н.В., Гулько Р.М. Кафедра фармакогнозії та ботаніки //Сув’язь поколінь. Фармацевтичний факультет Львівського національного медичного університету імені Данила Галицького: 1853-2009. - Львів, Наутілус, 2009. –с.216-267.
  • Шаповалова Н.В., Рибак О.В. Аналіз лікарської рослинної сировини за аналітичною нормативною документацією. - Львів, 2010. – 84с.
  • Бензель Л.В., Дармограй Р.Є., Олійник П.В., Бензель І.Л. Лікарські рослини і фітотерапія (фітотерапевтична рецептура). - К.: ВСВ “Медицина”, 2010. – 400 с.
  • Бензель Л.В., Олийник П.В., Бензель И.Л., Олийник С.П., Бабий В.Е. Лекарственные пищевые растения. - К.: ВСИ “Медицина”, 2010. – 344с.
  • Vorobets N. Plant Kingdom. Vascular plants: Flowering Plants. Selected Families of Flowering Plants: Main characteristics, classification and medical importance. - Lviv, 2010. – 260 р.
  • Черпак О.М. Методичні вказівки до лабораторних занять з ботаніки для студентів ІІ курсу фармацевтичного факультету. Cистематика і морфологія рослин. Розділ ІІ Систематика і морфологія  покритонасінних рослин. (Підкласи: ранункуліди, каріофіліди,  розіди, ліліїди). - Львів, 2010. – 87 с.
  • Шаповалова Н.В., Дармограй Р.Є. Ресурсознавство лікарських рослин. Методичні вказівки для студентів факультету заочного навчання спеціальності «Фармація». - Львів, 2010. – 48 с.
  • Черпак О.М. Збірник тестових завдань з фармацевтичної ботаніки для самостійної підготовки студентів фармацевтичного факультету для ліцензованого інтегрованого іспиту ,,Крок 1. Фармація”. - Львів, 2010. – 115 с.
  • Сметаніна К.І., Рибак О.В. Фармацевтичні аспекти профілактичного використання біологічно активних добавок рослинного походження. Методичні рекомендації для самостійної роботи слухачів курсів підвищення кваліфікації, спеціалістів із “Загальної фармації” та “Організація і управління фармацією”, провізорів-інтернів, студентів фармацевтичних ВНЗ ІІІ-ІV рівнів акредитації. - Львів, 2011. – 37 с.
  • Сметаніна К.І., Слабий М.В., Рибак О.В., Колач Т.С. Фармацевтична допомога при відпуску лікарських засобів і парафармацевтичної продукції, виготовлених на основі ехінацеї. Методичні рекомендації для самостійної роботи слухачів курсів підвищення кваліфікації, спеціалістів із “Загальної фармації” та “Організації і управління фармацією”, провізорів-інтернів, студентів фармацевтичних ВНЗ ІІІ-ІV рівнів акредитації. - Львів, 2011. – 42 с.
  • Antonyuk V.O., Lysiuk R.M., Antonyuk L.Y. A Practical Course of Pharmacognosy. - Lviv: LNMU,  2011. – 499 р.
  • Шаповалова Н.В., Дармограй Р.Є, Марчишин С.М. Навчальна практика з фармакогнозії: Типова програма навчальної дисципліни для студентів вищого навчального закладу та фармацевтичних факультетів вищих навчальних закладів ІІІ-ІУ рівнів акредитації спеціальності 7.110202 «Технологія парфумерно-косметичних засобів». - Київ, 2011. – 19 с.
  • Antonyuk V.O., Lysiuk R.M., Antonyuk L.Ya. A Laboratory Manual on Pharmacognosy. Lviv: LNMU, 2012. – 220 р.
  • R.M. Lysiuk, V.O. Antonyuk. A Textbook of Pharmacognosy / www.pharmacognosy.org.ua
  • Шаповалова Н.В., Дармограй Р.Є., Цаль О.Я. Навчальна практика з фармакогнозії за кредитно-модульною системою організації навчального процесу. - Львів, 2012. – 105 с.
  • Воробець Н.М. Збірник тестових і контрольних завдань з фармацевтичної ботаніки (розділ анатомія та морфологія рослин) Львів,  Вид-во ЛНМУ. – 2012. – 107 с.  
  • Vorobets N. Plant Kingdom. Bryophytes. Seedless Vascular Plants: Ferns and their relatives/ Gymnosperms/ Main characteristics, classification, and medical importance. - Lviv, 2012. -  46 р.  
  • Шаповалова Н.В., Цаль О.Я. Аналіз лікарської рослинної сировини, що вміщує сапоніни. - Львів, 2012. – 35 с.
  • Шаповалова Н.В., Рибак О.В. Аналіз лікарської рослинної сировини, що вміщує полісахариди. - Львів, 2012. – 20 с.
  • Шаповалова Н.В., Рибак О.В. Аналіз лікарської рослинної сировини, що вміщує вітаміни. - Львів, 2012. – 27 с.
  • Аналіз лікарської рослинної сировини, що вміщує серцеві глікозиди (кардіостероїди): методичні рекомендації до лабораторних занять з фармакогнозії для студентів ІІІ курсу фармацевтичного факультету спеціальності фармація / укл. І.Л.Бензель, Л.В.Бензель. – Львів, 2012. – 93с. 
  • Аналіз лікарської рослинної сировини, що вміщує алкалоїди: методичні рекомендації до лабораторних занять з фармакогнозії для студентів ІІІ курсу фармацевтичного факультету спеціальності “Фармація” / укл. І.Л.Бензель, Л.В.Бензель. – Львів, 2012. – 145 с.
  • P.V. Oliynyk, T.G. Kalynyuk, Lysiuk R.M. Extreme Medicine: Textbook for Stud. of Higher Institution and Faculties of Pharmacy // Lviv: LNMU, 2013. – 201 p.
  • Черпак О.М.     Навчально-методичний посібник для лабораторної і самостійної роботи студентів П курсу фармацевтичного факультету «Фармацевтична ботаніка. Частина I. Анатомія рослин» ”/О.М. Черпак,  Р.Є. Дармограй,  Н.В.Шаповалова, - Вид-во ЛГМУ ім.Д.Галицького. - Львів, 2014. – 104 с.
  • Черпак О.М., Шаповалова Н.В., Дармограй Р.Є. Методичні рекомендації до лабораторних занять та самостійної роботи з фармацевтичної ботаніки до змістового модуля «Морфологія вегетативних органів рослин» для студентів ІІ курсу фармацевтичного факультету спеціальності «Фармація». – Львів, 2014. – 50 с.
  • Рибак О.В., Дармограй Р.Є., Шаповалова Н.В. Методичні рекомендації до виконання курсових робіт з фармакогнозії для студентів ІІІ курсу фармацевтичного факультету: Методичні рекомендації для студентів ІІІ курсу фармацевтичного факультету спеціальностей „Фармація” та „Клінічна фармація” . – Львів, 2014. – 68 с.
  • Лисюк Р.М., Шляхта Я. М. Цілющі деревні рослини: навч. посіб.-довідн. // К.: Знання, 2014. - 221с.+32 с. іл..

NEW EDITIONS OF THE DEPARTMENT

The first electronic textbook of Pharmacognosy in English ''A Textbook of Pharmacognosy'' is prepared by the co-workers at department of Pharmacognosy and Botany Danylo Halytsky Lviv National Medical University assist. prof. R.M. Lysyuk and prof., DSci. (Pharm) V.O. Antonyuk, in accordance with the typical program of the subject "Pharmacognosy" for students of higher pharmaceutical institution and Pharmacy faculties at higher educational institutions of III-IV levels of accreditation (Kyiv, 2011) for English medium students of Pharmacy faculty (specialty 8.110201 - "Pharmacy").

Electronic textbook is developed on the basis of the program "Microsoft Office Publisher 2007" with the possibility of on – line (www.pharmacognosy.org.ua) and off - line access. Possibility for variation of familiarization sequence with the content of a hypertext, as opposed to the linear text, is reached by division of information on segments (themes) and the establishment of links between them, allowing the user to move from the current studied theme to one of several related themes.

By the coworkers of the Department of Pharmacognosy and Botany at Danylo Halytsky Lviv National Medical University was published the first in Ukraine ''A Laboratory Manual of Pharmacognosy'' for students of English medium (recommended by the Ministry of Education and Sciences, Youth and Sports of Ukraine as a manual, letter № 1/11-496 from 16.01. 2012), prepared by native authors and complied in accordance with the curriculum based on the principles of ECTS.

Definitions of major pharmacognostic terms concern kinds of medicinal plant materials (MPM), methods of analysis, quality control and standardization of phytopharmaceuticals. The current techniques for analysis of herbal drugs in accordance with the European Pharmacopoeia are given within the correspondent chapters. Special chapters are dedicated to batch quality analysis, sampling, macroscopic and microscopic, microchemical analyses of plant materials, analysis of herbal collections (Species) and powdered materials; also Bibliography in Pharmacy and Pharmacognosy, the journals on Pharmacognosy, Pharmacological classification of medicinal plants.

Each chapter is provided by information for better preparation of students for practical training: actuality; learning objectives; a list of relevant literature; test and program questions; examples of tests; items for homework; the detailed characteristics of the objects of analysis (plant image, MPM definition, distribution, morphological and microscopic characters, constituents, pharmacological effects, medicinal application); comparative morphological characteristics of possible adulterants; methods of fulfillment of practical tasks.

For classes of biologically active natural compounds are given classification, physical and chemical properties, methods of extraction from MPM, detection, chromatographic methods of analysis, quantitative assays, major activities. They comprise polysaccharides and glycosides, fixed oils, vitamins, simple phenols and their derivatives, coumarins and chromones, flavonoids, tannins, anthraquinones, lignans, xanthones, iridoids, volatile oils (monoterpenoids, sesquiterpenoids, aromatic compounds), triterpenoids and saponins, steroids, cardiac glycosides, alkaloids. 

Educational and methodological provision

Pharmacognosy

Pharmaceutical botany                 

Resources of medicinal plants